Proteins provide the chemical basis for all processes of life. We investigate their origin and the evolution of their folds and mechanisms of action by means of bioinformatics, biochemistry and structural biology.
The Department of Microbiome Science is broadly interested in how interactions between humans and their gut microbiota influence metabolism and obesity. We explore how interactions between host genetic status and the microbiome influence host metabolic phenotypes.
How do developmental processes change during evolution? We take an integrative approach and try to link evo-devo with population genetics and evolutionary ecology by studying the nematode Pristionchus pacificus, which lives in a defined scarab beetle ecosystem.
There is tremendous phenotypic diversity between and within species. Much of this is thought to reflect adaptation to the environment. Drawing on tools from high-throughput genomics to forward genetics, we are investigating the mechanisms responsible for adaptive variation.